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regimen-monograph
MAID
| ifosfamide
(Round to nearest 25 mg) |
2500 mg /m²/day | IV continuous Infusion over 24 hours | Starting day 1 for 72 hours |
| mesna
(Round to nearest 1 mg) |
1500 mg /m²/day | IV continuous Infusion over 24 hours | Starting day 1 for 96 hours |
| DOXOrubicin
(Round to nearest 1.0 mg) |
20 mg /m²/day | IV Continuous Infusion over 24 hours | Starting day 1 for 72 hours (Inpatient) |
|
[[]OR give as Doxorubicin IV Daily for 3 days (Outpatient)]
|
|||
| dacarbazine
(Round to nearest 1.0 mg) |
300 mg /m²/day | IV continuous Infusion over 24 hours | Starting Day 1 for 72 hours (Inpatient) |
|
[[]OR give as Dacarbazine IV daily for 3 days (Outpatient)]
|
|||
REPEAT EVERY 21 DAYS
For a usual total of 4 to 6 cycles unless disease progression or unacceptable toxicity occurs.
Doses should be modified according to the protocol by which the patient is being treated. The following recommendations are in use at some centres.
Dosage with toxicity
Hematologic Toxicities: Refer to Appendix 6 for general recommendations.
Hepatic Impairment
|
Bilirubin levels
|
Action
|
|
If Bilirubin 1-2 x ULN
|
REDUCE Doxorubicin* to 50 % dose
|
|
If Bilirubin 2-4 x ULN
|
REDUCE Doxorubicin to 25 % dose
|
|
If Bilirubin > 4 x ULN
|
OMIT Doxorubicin dose
|
Renal Impairment
|
Clearance or Serum Creatinine
|
Ifosfamide Dose
|
|
If CrCl <0.5mL/sec or
Serum Creatinine > 185µmol/L
|
REDUCE Ifosfamide to 75% dose
|
|
If CrCl <0.2mL/sec or
Serum Creatinine >300µmol/L
|
REDUCE Ifosfamide to 67% dose
|
Creatinine Clearance (mL/min) |
Dacarbazine Dose* |
>50 |
100% of dose |
30-50 |
75% of dose |
10-30 |
50% or discontinue |
<10 |
discontinue |
* modified from Kintzel et al 1995
Recommended Clinical Monitoring
- Clinical toxicity (including stomatitis, neurotoxicity, cystitis, local toxicity, skin, cardiotoxicity) assessment.
- CBC before each cycle.
- Baseline and regular liver function tests.
- Baseline and regular renal function tests (including electrolytes and magnesium) and urinalysis.
- Cardiac examination especially with risk factors (including prior therapy with Epirubicin, Mitoxantrone, or other cardiotoxic drug), or a cumulative Doxorubicin dose of > 450 mg/m2
- Grade toxicity using the current NCI-CTCAE (Common Terminology Criteria for Adverse Events) version
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Antman K, Crowley J, Balcerzak SP, et al, An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J Clin Oncol, 1989; 7: 1655-1659
CCO Practice Guideline: Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma.
Sarcomas are rare tumours and as such benefit from referral to specialized centres where there will be access to multidisciplinary expertise including good radiology, orthopedic and thoracic surgery, medical oncology, radiation oncology, pathology, and other supportive care disciplines.
September 2011: regimen archived
Regimen Abstracts
A Regimen Abstract is an abbreviated version of a Regimen Monograph and contains only top level information on usage, dosing, schedule, cycle length and special notes (if available). It is intended for healthcare providers and is to be used for informational purposes only. It is not intended to constitute or be a substitute for medical advice, and all uses of the Regimen Abstract are subject to clinical judgment. Such information is provided on an “as-is” basis, without any representation, warranty, or condition, whether express, or implied, statutory or otherwise, as to the information’s quality, accuracy, currency, completeness, or reliability, and Cancer Care Ontario disclaims all liability for the use of this information, and for any claims, actions, demands or suits that arise from such use.
Information in regimen abstracts is accurate to the extent of the ST-QBP regimen master listings, and has not undergone the full review process of a regimen monograph. Full regimen monographs will be published for each ST-QBP regimen as they are developed.
Regimen Monographs
Refer to the New Drug Funding Program or Ontario Public Drug Programs websites for the most up-to-date public funding information.
The information set out in the drug monographs, regimen monographs, appendices and symptom management information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare providers and is to be used for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects of a particular drug, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for a given condition. The information in the Formulary is not intended to constitute or be a substitute for medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.
The format and content of the drug monographs, regimen monographs, appendices and symptom management information contained in the Formulary will change as they are reviewed and revised on a periodic basis. The date of last revision will be visible on each page of the monograph and regimen. Since standards of usage are constantly evolving, it is advised that the Formulary not be used as the sole source of information. It is strongly recommended that original references or product monograph be consulted prior to using a chemotherapy regimen for the first time.
Some Formulary documents, such as the medication information sheets, regimen information sheets and symptom management information (for patients), are intended for patients. Patients should always consult with their healthcare provider if they have questions regarding any information set out in the Formulary documents.
While care has been taken in the preparation of the information contained in the Formulary, such information is provided on an “as-is” basis, without any representation, warranty, or condition, whether express, or implied, statutory or otherwise, as to the information’s quality, accuracy, currency, completeness, or reliability.
CCO and the Formulary’s content providers shall have no liability, whether direct, indirect, consequential, contingent, special, or incidental, related to or arising from the information in the Formulary or its use thereof, whether based on breach of contract or tort (including negligence), and even if advised of the possibility thereof. Anyone using the information in the Formulary does so at his or her own risk, and by using such information, agrees to indemnify CCO and its content providers from any and all liability, loss, damages, costs and expenses (including legal fees and expenses) arising from such person’s use of the information in the Formulary.
Last Updated: July 21, 2026