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regimen-monograph
CRBPETOP(PO)
(recurrent medulloblastoma, recurrent malignant glioma)
Adjuvant
etoposide
ODB - General Benefit (etoposide - oral capsules)
| CARBOplatin
(Round to nearest 1mg) |
500 mg /m² | IV over 1 hour | Day 1 |
|
Adjust Carboplatin dose to AUC target (using Calvert formula) or in response to platelet counts (using Egorin formula -if previously treated with thrombocytopenic agent), as outlined in "Other Notes" section.
|
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| etoposide | 50 mg | PO | Days 1 to 14 |
|
|
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REPEAT EVERY 28 DAYS
4 cycles concurrent with Radiotherapy and 4 cycles post-Radiotherapy
Moderate (Carboplatin)
Low (Etoposide)
Doses should be modified according to the protocol by which the patient is being treated. The following recommendations are in use at some centres.
Dosage with toxicity
Hematologic Toxicities: Refer to appendix 6 for general recommendations.
If platelets < 100 x 109/L, ADJUST Carboplatin dose as described in Egorin Formula
Hepatic Impairment
| Bilirubin | Etoposide (% of usual dose) |
| 1-2 x ULN | REDUCE Etoposide to 50% dose |
| 2-4 x ULN | REDUCE Etoposide to 25% dose |
| >4 x ULN | STOP treatment with Etoposide |
Renal Impairment
Carboplatin (suggested):
Creatinine Clearance (ml/min) |
Carboplatin (% previous dose)
|
20 - 50 |
Use Calvert or Chatelut formula
|
< 20 |
Discontinue
|
Etoposide (suggested):
Creatinine clearance (mL/min) |
% usual dose |
15-50 |
75 |
<15 |
50, or discontinue |
Refer to CARBOplatin, etoposide drug monograph(s) for additional details
Recommended Clinical Monitoring
- Clinical toxicity (including stomatitis, neurotoxicity, ototoxicity, and local toxicity) assessment
- CBC before each cycle
- Baseline and regular liver function tests
- Baseline and regular renal function tests and urinalysis
- Grade toxicity using the current NCI-CTCAE (Common Terminology Criteria for Adverse Events) version
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Gentet JC, Doz F, Bouffett E, et al. Carboplatin and VP 16 I medulloblastoma: a phase II study of the French Society of Peditric Oncology (SFOP). Med Pediatric Oncology 1994; 23 (5): 422-7.
October 2017 Formatted public funding and renal impairment sections
- Target AUC of 4 to 6 mg/mL·min (previously treated patients) or 6 to 8 mg/mL·min (previously untreated patients)
- AUC = product of serum concentration (mg/mL) and time (min)
- GFR (glomerular filtration rate) expressed as measured Creatinine Clearance or estimated from Serum Creatinine (by Cockcroft and Gault method or Jelliffe method)
- Pre = pretreatment platelet count
- Nadir = platelet nadir desired
- BSA = Body Surface Area
- Cr Cl = Creatinine Clearance
(Egorin MJ, Van Echo DA, Tiping SJ, et al, Pharmacokinetics and dosage reduction of carboplatin in patients with impaired renal function. Cancer Res, 1984; 44: 5432-5438)
Regimen Abstracts
A Regimen Abstract is an abbreviated version of a Regimen Monograph and contains only top level information on usage, dosing, schedule, cycle length and special notes (if available). It is intended for healthcare providers and is to be used for informational purposes only. It is not intended to constitute or be a substitute for medical advice, and all uses of the Regimen Abstract are subject to clinical judgment. Such information is provided on an “as-is” basis, without any representation, warranty, or condition, whether express, or implied, statutory or otherwise, as to the information’s quality, accuracy, currency, completeness, or reliability, and Cancer Care Ontario disclaims all liability for the use of this information, and for any claims, actions, demands or suits that arise from such use.
Information in regimen abstracts is accurate to the extent of the ST-QBP regimen master listings, and has not undergone the full review process of a regimen monograph. Full regimen monographs will be published for each ST-QBP regimen as they are developed.
Regimen Monographs
Refer to the New Drug Funding Program or Ontario Public Drug Programs websites for the most up-to-date public funding information.
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Last Updated: July 21, 2026