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regimen-monograph
DCRBDOXO(CIV); CRBPDCRB(CIV)
(Desmoid Tumours)
| dacarbazine
(Round to nearest 5mg) |
1000* mg /m² | IV continuous infusion | Starting day 1; Infuse over 4 days |
| DOXOrubicin
(Round to nearest 1 mg) |
60-90* mg /m² | IV continuous infusion | Starting day 1; Infuse over 4 days |
|
After 7 cycles with Doxorubicin/Dacarbazine, in order to prevent cardiotoxicity, replace Doxorubicin with: |
|||
| CARBOplatin
(Round to nearest 10mg) |
400* mg /m² | IV continuous infusion | Starting day 1; Infuse over 4 days |
|
*Total dose per cycle
|
|||
REPEAT EVERY 21 DAYS
Until evidence of disease progression or limited by cardiotoxicity or other drug toxicity
Doses should be modified according to the protocol by which the patient is being treated. The following recommendations are in use at some centres.
Dosage with toxicity
Hematologic Toxicities: Refer to Appendix 6 for general recommendations
Hepatic Impairment
Bilirubin |
% Doxorubicin Usual Dose |
1-2x ULN |
50% |
2-4x ULN |
25% |
>4 xULN |
OMIT (suggested action) |
Renal Impairment
Creatinine Clearance (mL/min) |
Dacarbazine Dose* |
>50 |
100% of dose |
30-50 |
75% of dose |
10-30 |
50% or discontinue |
<10 |
discontinue |
* modified from Kintzel et al 1995
(See "Other Notes" section).
Recommended Clinical Monitoring
- Clinical toxicity (including stomatitis, local toxicity, cardiotoxicity, skin) assessment.
- CBC before each cycle.
- Baseline and regular liver & renal function tests.
- Cardiac examination especially with risk factors (including prior therapy with Epirubicin, Mitoxantrone, or other cardiotoxic drug), or a cumulative Doxorubicin dose of > 450 mg/m2.
- Grade toxicity using the current NCI-CTCAE (Common Terminology Criteria for Adverse Events) version
Suggested Clinical Monitoring
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Sarcomas are rare tumours and as such benefit from referral to specialized centres where there will be access to multidisciplinary expertise including good radiology, orthopedic and thoracic surgery, medical oncology, radiation oncology, pathology, and other supportive care disciplines.
Egorin Formula
Previously Untreated Patients -
DOSE (mg/m2) = 317{ (pre - nadir/pre) 100 - 82.1} X (BSA/Cr Cl) + 447
Previously Treated Patients -
DOSE (mg/m2) = 317{ (pre - nadir/pre) 100 - 92.4} X (BSA/Cr Cl) + 447
- Pre = pretreatment platelet count
- Nadir = platelet nadir desired
- BSA = Body Surface Area
- Cr Cl = Creatinine Clearance
Reference: Egorin MJ, Van Echo DA, Tiping SJ, et al. Pharmacokinetics and dosage reduction of carboplatin in patients with impaired renal function. Cancer Res, 1984; 44: 5432-5438
September 2011: regimen archived
Regimen Abstracts
A Regimen Abstract is an abbreviated version of a Regimen Monograph and contains only top level information on usage, dosing, schedule, cycle length and special notes (if available). It is intended for healthcare providers and is to be used for informational purposes only. It is not intended to constitute or be a substitute for medical advice, and all uses of the Regimen Abstract are subject to clinical judgment. Such information is provided on an “as-is” basis, without any representation, warranty, or condition, whether express, or implied, statutory or otherwise, as to the information’s quality, accuracy, currency, completeness, or reliability, and Cancer Care Ontario disclaims all liability for the use of this information, and for any claims, actions, demands or suits that arise from such use.
Information in regimen abstracts is accurate to the extent of the ST-QBP regimen master listings, and has not undergone the full review process of a regimen monograph. Full regimen monographs will be published for each ST-QBP regimen as they are developed.
Regimen Monographs
Refer to the New Drug Funding Program or Ontario Public Drug Programs websites for the most up-to-date public funding information.
The information set out in the drug monographs, regimen monographs, appendices and symptom management information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare providers and is to be used for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects of a particular drug, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for a given condition. The information in the Formulary is not intended to constitute or be a substitute for medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.
The format and content of the drug monographs, regimen monographs, appendices and symptom management information contained in the Formulary will change as they are reviewed and revised on a periodic basis. The date of last revision will be visible on each page of the monograph and regimen. Since standards of usage are constantly evolving, it is advised that the Formulary not be used as the sole source of information. It is strongly recommended that original references or product monograph be consulted prior to using a chemotherapy regimen for the first time.
Some Formulary documents, such as the medication information sheets, regimen information sheets and symptom management information (for patients), are intended for patients. Patients should always consult with their healthcare provider if they have questions regarding any information set out in the Formulary documents.
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Last Updated: July 27, 2026